A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

Last updated:
2026-08-29
Language and content disclaimer

The content and search results on this site are collected from or provided by third parties. As such some of the information may only be available in the language originally submitted by the sponsor of the trial. Learn more about the information on the search portal.

Linking to Non-Government of Canada Websites

Links to websites not under the control of the Government of Canada, including those to our social media accounts, and to clinical trial records in international registries are provided solely for the convenience of our website visitors. We are not responsible for the accuracy, currency or reliability of the content of such websites. The Government of Canada does not offer any guarantee in that regard and is not responsible for the information found through these links, nor does it endorse the sites and their content.

Visitors should also be aware that information offered by non-Government of Canada sites to which this website links is not subject to the Privacy Act or the Official Languages Act and may not be accessible to persons with disabilities. The information offered may be available only in the language(s) used by the sites in question. With respect to privacy, visitors should research the privacy policies of these non-government websites before providing personal information.

View trial details

Overview

Official protocol title:

A PHASE 3, RANDOMIZED, OPEN-LABEL STUDY TO EVALUATE THE EFFICACY AND SAFETY OF SAC-TMT (SACITUZUMAB TIRUMOTECAN, MK-2870) FOLLOWED BY CARBOPLATIN/PACLITAXEL VS CHEMOTHERAPY, BOTH IN COMBINATION WITH PEMBROLIZUMAB AS NEOADJUVANT THERAPY FOR HIGH-RISK, EARLY-STAGE, TRIPLE NEGATIVE BREAST CANCER OR HORMONE RECEPTOR-LOW POSITIVE/HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR-2 NEGATIVE BREAST CANCER

Intervention/treatment:
MK-2870 [SACITUZUMAB TIRUMOTECAN (SKB264)] / MK-3475 [PEMBROLIZUMAB]
Medical condition:
BREAST CANCER
Protocol code:
MK-2870-032
Control number:
298745
Status:
Recruiting
Approved:
July 03, 2025
Trial phase:
Phase 3
For more information:
ClinicalTrials.gov - NCT06966700
This is an external link. The information is not authorized by the Government of Canada.

Eligibility

Sex: ALL
Age
18 Years and older
Accepts healthy volunteers: No

Contacts and locations

Contact
Name
Toll Free Number
Role
CONTACT
Phone:
1-888-577-8839
Sponsor
MERCK CANADA INC

Locations

British Columbia

BC Cancer - Surrey ( Site 0217)
Surrey, British Columbia, V3V 1Z2
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
604-930-2098
BC Cancer Vancouver ( Site 0218)
Vancouver, British Columbia, V5Z 4E6
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
604-877-6000

Newfoundland and Labrador

NL Health Services ( Site 0232)
St. John's, Newfoundland and Labrador, A1B 3V6
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
7097772638

Ontario

Health Sciences North ( Site 0234)
Greater Sudbury, Ontario, P3E 5J1
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
7055237100
Lakeridge Health ( Site 0225)
Oshawa, Ontario, L1G 2B9
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
9055768711
Princess Margaret Cancer Centre ( Site 0208)
Toronto, Ontario, M5G 2M9
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
4169462000
Royal Victoria Regional Health Centre ( Site 0233)
Barrie, Ontario, L4M 6M2
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
705-728-9802 x43529
Sault Area Hospital ( Site 0226)
Sault Ste. Marie, Ontario, P6B 0A8
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
705-759-3434
The Ottawa Hospital - General Campus-The Ottawa Hospital Cancer Centre ( Site 0209)
Ottawa, Ontario, K1H 8L6
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
6137377700

Quebec

Centre Hospitalier de l'Université de Montréal ( Site 0201)
Montreal, Quebec, H2X 3E4
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
5148908000
Centre integre universitaire de sante et de services sociaux de la Mauricie-et-du-centre-du-quebec ( Site 0204)
Trois-Rivières, Quebec, G8Z 3R9
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
8196973333x63238
Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer ( Site 0206)
Sherbrooke, Quebec, J1H 5N4
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
8193461110
CHU de Quebec Universite Laval - Hopital du Saint-Sacrement ( Site 0203)
Québec, Quebec, G1S 4L8
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
4185254444
Jewish General Hospital ( Site 0200)
Montreal, Quebec, H3T 1E2
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
514-340-8222
McGill University Health Centre ( Site 0202)
Montreal, Quebec, H4A 3J1
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
5149341934
Did you find what you were looking for?

Contacts and resources