A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)

Last updated:
2026-08-22
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View trial details

Overview

Official protocol title:

A MASTER PROTOCOL FOR A RANDOMIZED, CONTROLLED, CLINICAL TRIAL OF MULTIPLE PHARMACOLOGIC AGENTS IN ADULT PARTICIPANTS WITH METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE WHO ARE AT INCREASED RISK OF DEVELOPING MAJOR ADVERSE LIVER OUTCOMES (SYNERGY-OUTCOMES)

Intervention/treatment:
TIRZEPATIDE (LY3298176) / RETATRUTIDE (LY3437943)
Medical condition:
METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE (MASLD)
Protocol code:
N1T-MC-MALO
Control number:
302258
Status:
Recruiting
Approved:
November 06, 2025
Trial phase:
Phase 3
For more information:
ClinicalTrials.gov - NCT07165028
This is an external link. The information is not authorized by the Government of Canada.

Eligibility

Sex: ALL
Age
18 Years and older
Accepts healthy volunteers: No

Contacts and locations

Contact
Name
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
Role
CONTACT
Phone:
1-317-615-4559
Name
Physicians interested in becoming principal investigators please contact
Role
CONTACT
Sponsor
ELI LILLY CANADA INC

Locations

(G.I.R.I.) GI Research Institute Foundation
Vancouver, V5Z 2K5
Not yet recruiting
Name
Alnoor Ramji
Role
PRINCIPAL_INVESTIGATOR
Phone:
204 789 3950
Clinical Research of Ontario
Toronto, M1S 4T7
Recruiting
Role
CONTACT
Phone:
18002474525
Name
Gerald Chan
Role
PRINCIPAL_INVESTIGATOR
Diex Recherche Inc. Division Trois-Rivieres
Trois-Rivières, G9A 4P3
Recruiting
Name
Jean-francois Naud
Role
PRINCIPAL_INVESTIGATOR
Diex Recherche Quebec
Québec, G1V 4T3
Recruiting
Name
Marie-Philippe Morin
Role
PRINCIPAL_INVESTIGATOR
Phone:
18002474525
Ecogene-21
Chicoutimi, G7H 7K9
Recruiting
Role
CONTACT
Phone:
418-545-1252
Name
Daniel Gaudet
Role
PRINCIPAL_INVESTIGATOR
Health Sciences Centre Winnipeg
Winnipeg, R3A 1R9
Not yet recruiting
Role
CONTACT
Phone:
204 789 3950
Name
Nabiha Faisal
Role
PRINCIPAL_INVESTIGATOR
Heritage Medical Research Clinic
Calgary, T2N 4Z6
Not yet recruiting
Role
CONTACT
Phone:
4032109240
Name
Mark Swain
Role
PRINCIPAL_INVESTIGATOR
Private Practice - Dr. Stephane M. Gauthier
North Bay, P1B 2H3
Recruiting
Name
Marie-Philippe Morin
Role
CONTACT
Phone:
7054767737
Name
Stephane Gauthier
Role
PRINCIPAL_INVESTIGATOR
QEII Health Sciences Centre - Victoria General Site
Halifax, B3H 2Y9
Not yet recruiting
Name
Julie Zhu
Role
PRINCIPAL_INVESTIGATOR
St. Joseph's Health Centre
Toronto, M6R 1B5
Not yet recruiting
Name
Ian Bookman
Role
PRINCIPAL_INVESTIGATOR
Toronto General Hospital
Toronto, M5G 2C4
Not yet recruiting
Name
Ian Bookman
Role
CONTACT
Phone:
4163403312
Name
Keyur Patel
Role
PRINCIPAL_INVESTIGATOR
University Hospital - London Health Sciences Centre
London, N6A 5A5
Not yet recruiting
Name
Mohammad Qasim Khan
Role
PRINCIPAL_INVESTIGATOR
Phone:
7054767737
University Of Alberta Hospital
Edmonton, T6G 2C8
Not yet recruiting
Name
Ellina Lytvyak
Role
PRINCIPAL_INVESTIGATOR
Vancouver General Hospital
Vancouver, V5Z 1M9
Not yet recruiting
Name
Peter W.C. Kwan
Role
PRINCIPAL_INVESTIGATOR
Wells Research Group
Edmonton, T5L 4G4
Recruiting
Role
CONTACT
Phone:
5879863393
Name
Malcolm Wells
Role
PRINCIPAL_INVESTIGATOR
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