Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

Last updated:
2026-09-19
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View trial details

Overview

Official protocol title:

ZENITH: A PHASE 3 GLOBAL, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF ZILEBESIRAN IN ADDITION TO STANDARD OF CARE IN REDUCING MAJOR ADVERSE CARDIOVASCULAR EVENTS IN ADULT PATIENTS WITH HYPERTENSION NOT ADEQUATELY CONTROLLED AND WITH EITHER ESTABLISHED CARDIOVASCULAR DISEASE OR HIGH RISK FOR CARDIOVASCULAR DISEASE

Intervention/treatment:
ZILEBESIRAN (ALN-AGT01)
Medical condition:
CARDIOVASCULAR DISEASE
Protocol code:
ALN-AGT01-008
Control number:
301098
Status:
Recruiting
Approved:
September 22, 2025
Trial phase:
Phase 3
For more information:
ClinicalTrials.gov - NCT07181109
This is an external link. The information is not authorized by the Government of Canada.

Eligibility

Sex: ALL
Age
18 Years and older
Accepts healthy volunteers: No

Contacts and locations

Contact
Name
Clinical Trial Information Line
Role
CONTACT
Phone:
1-877-ALNYLAM
Name
Clinical Trial Information Line
Role
CONTACT
Phone:
1-877-256-9526
Sponsor
ALNYLAM PHARMACEUTICALS INC

Locations

Clinical Trial Site
Brampton, L6S 0C6
RECRUITING
Clinical Trial Site
Brampton, L6Z 4N5
RECRUITING
Clinical Trial Site
Burlington, L7M 1K9
RECRUITING
Clinical Trial Site
Cambridge, N1R 7R1
NOT_YET_RECRUITING
Clinical Trial Site
Chicoutimi, G7H 7K9
RECRUITING
Clinical Trial Site
Etobicoke, M8Z 4E4
RECRUITING
Clinical Trial Site
Etobicoke, M9R 4E1
RECRUITING
Clinical Trial Site
Greater Sudbury, P3C 1S8
RECRUITING
Clinical Trial Site
Laval, H7T 2P5
RECRUITING
Clinical Trial Site
Levis, G6W 0M5
RECRUITING
Clinical Trial Site
London, N6A 5W9
NOT_YET_RECRUITING
Clinical Trial Site
Longueuil, J4H 4B9
RECRUITING
Clinical Trial Site
Mirabel, J7J 2K8
RECRUITING
Clinical Trial Site
Mississauga, L5K 2L3
RECRUITING
Clinical Trial Site
Moncton, E1C 2Z3
RECRUITING
Clinical Trial Site
Moncton, E1G 5C4
RECRUITING
Clinical Trial Site
Montreal, H1M 1B1
RECRUITING
Clinical Trial Site
Montreal, H1M 1L3
RECRUITING
Clinical Trial Site
Peterborough, K9J 0B2
RECRUITING
Clinical Trial Site
Quebec, G1L 3L5
RECRUITING
Clinical Trial Site
Quebec, G1R 2J6
RECRUITING
Clinical Trial Site
Quebec, G1V 4G5
RECRUITING
Clinical Trial Site
Richmond, V6V 2X3
RECRUITING
Clinical Trial Site
Rimouski, G5L 5T1
NOT_YET_RECRUITING
Clinical Trial Site
Saint-Jérôme, J7Z 2V4
RECRUITING
Clinical Trial Site
Sarnia, N7T 4X3
NOT_YET_RECRUITING
Clinical Trial Site
Scarborough, M1B 4Z8
RECRUITING
Clinical Trial Site
Scarborough, M1B 5N1
NOT_YET_RECRUITING
Clinical Trial Site
Sherbrooke, 8193462887
RECRUITING
Clinical Trial Site
Sherbrooke, J1H 5N4
NOT_YET_RECRUITING
Clinical Trial Site
Sydney, B1S 0K1
RECRUITING
Clinical Trial Site
Trois Rivieres, G9A 4P3
NOT_YET_RECRUITING
Clinical Trial Site
Windsor, N8X 1L9
NOT_YET_RECRUITING
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