A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)

Last updated:
2026-08-15
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View trial details

Overview

Official protocol title:

A RANDOMIZED, OPEN-LABEL, PHASE 2/3 STUDY OF IZALONTAMAB BRENGITECAN (BMS-986507) VERSUS TREATMENT OF PHYSICIAN’S CHOICE IN PATIENTS WITH PREVIOUSLY UNTREATED, LOCALLY ADVANCED, RECURRENT INOPERABLE, OR METASTATIC TRIPLE-NEGATIVE BREAST CANCER (TNBC) OR ER-LOW, HER2-NEGATIVE BC WHO ARE INELIGIBLE FOR ANTI-PD1/PD-L1 TREATMENT

Intervention/treatment:
BMS-986507 / CAPECITABINE / PACLITAXEL / CARBOPLATIN
Medical condition:
BREAST CANCER METASTATIC TRIPLE NEGATIVE
Protocol code:
CA244-0008
Control number:
297494
Status:
Recruiting
Approved:
June 06, 2025
Trial phase:
Phase 2, Phase 3
For more information:
ClinicalTrials.gov - NCT06926868
This is an external link. The information is not authorized by the Government of Canada.

Eligibility

Sex: ALL
Age
18 Years and older
Accepts healthy volunteers: No

Contacts and locations

Contact
Name
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
Role
CONTACT
Phone:
855-907-3286
Name
First line of the email MUST contain NCT # and Site #.
Role
CONTACT
Sponsor
BRISTOL-MYERS SQUIBB CANADA

Locations

British Columbia

BC Cancer Kelowna
Kelowna, British Columbia, V1Y 5L3
Recruiting
Name
Susan Ellard, Site 0218
Role
CONTACT
Phone:
+1250-712-3996
Local Institution - 0217
Victoria, British Columbia, V8R 6V5
Not yet recruiting
Name
Site 0217
Role
CONTACT

Ontario

The Ottawa Hospital - General Campus
Ottawa, Ontario, K1H 8L6
Recruiting
Name
Xinni Song, Site 0265
Role
CONTACT
Phone:
6137377700ext70208

Quebec

Centre Hospitalier de l'Université de Montréal
Montreal, Quebec, H2X 3E4
Recruiting
Name
Danielle Charpentier, Site 0215
Role
CONTACT
Phone:
5148908000
Centre Intégré de Santé et de Services Sociaux de Lanaudière
Saint-Charles-Borromee, Quebec, J6E 6J2
Recruiting
Name
Angélique Brunot, Site 0350
Role
CONTACT
Phone:
579-593-1172
Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke (CIUS
Sherbrooke, Quebec, J1H 5N4
Recruiting
Name
Michel Pavic, Site 0216
Role
CONTACT
Phone:
819-346-1110x74816
McGill University Health Centre
Montreal, Quebec, H4A 3J1
Recruiting
Name
Jamil Asselah, Site 0219
Role
CONTACT
Phone:
514934193435721
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