A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

Last updated:
2026-07-18
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View trial details

Overview

Official protocol title:

EASI-HF REDUCED - A PHASE III DOUBLE-BLIND, RANDOMISED, PARALLEL-GROUP SUPERIORITY TRIAL TO EVALUATE EFFICACY AND SAFETY OF THE COMBINED USE OF ORAL VICADROSTAT (BI 690517) AND EMPAGLIFLOZIN COMPARED WITH PLACEBO AND EMPAGLIFLOZIN IN PARTICIPANTS WITH SYMPTOMATIC CHRONIC HEART FAILURE (HF: NYHA II-IV) AND LEFT VENTRICULAR EJECTION FRACTION (LVEF) < 40%

Intervention/treatment:
VICADROSTAT (BI 690517) / EMPAGLIFLOZIN
Medical condition:
CHRONIC HEART FAILURE
Protocol code:
1378-0018
Control number:
296316
Status:
Recruiting
Approved:
April 16, 2025
Trial phase:
Phase 3
For more information:
ClinicalTrials.gov - NCT06935370
This is an external link. The information is not authorized by the Government of Canada.

Eligibility

Sex: ALL
Age
18 Years and older
Accepts healthy volunteers: No

Contacts and locations

Contact
Name
Boehringer Ingelheim
Role
CONTACT
Phone:
1-800-243-0127
Sponsor
BOEHRINGER INGELHEIM INTERNATIONAL GMBH

Locations

CardioVasc HR Inc.
Saint-Jean-sur-Richelieu, J3A 1J2
NOT_YET_RECRUITING
Name
Boehringer Ingelheim
Role
CONTACT
Phone:
18336022346

Ontario

CardioQuest Research Centre
Sarnia, Ontario, N7T 4P5
RECRUITING
Name
Boehringer Ingelheim
Role
CONTACT
Phone:
18336022346
CIUSSS du Saguenay - Lac-Saint-Jean
Québec, Ontario, G7H 5H6
NOT_YET_RECRUITING
Name
Boehringer Ingelheim
Role
CONTACT
Phone:
18336022346
Elevate Clinical Research - KMH Hamilton
Kitchener, Ontario, N2M 5N4
RECRUITING
Name
Boehringer Ingelheim
Role
CONTACT
Phone:
18336022346
Fadia El Boreky Medicine Professional Corporation
Waterloo, Ontario, N2J 1C4
RECRUITING
Name
Boehringer Ingelheim
Role
CONTACT
Phone:
18336022346
Health Sciences North
Greater Sudbury, Ontario, P3E 5J1
RECRUITING
Name
Boehringer Ingelheim
Role
CONTACT
Phone:
18336022346
James Cha, MD
Oshawa, Ontario, L1J 2K1
RECRUITING
Name
Boehringer Ingelheim
Role
CONTACT
Phone:
18336022346
Kawartha Cardiology Clinical Trials
Peterborough, Ontario, K9J 0B2
RECRUITING
Name
Boehringer Ingelheim
Role
CONTACT
Phone:
18336022346
KMH Cardiology Centres (Mississauga)
Mississauga, Ontario, L5K 2L3
RECRUITING
Name
Boehringer Ingelheim
Role
CONTACT
Phone:
18336022346
Niagara Health System - St. Catharines Site
St. Catharines, Ontario, L2R 7C6
NOT_YET_RECRUITING
Name
Boehringer Ingelheim
Role
CONTACT
Phone:
18336022346
Oakville Trafalgar Memorial Hospital
Oakville, Ontario, L6K 3W7
NOT_YET_RECRUITING
Name
Boehringer Ingelheim
Role
CONTACT
Phone:
18336022346
Premier Clinical Trial Network
Hamilton, Ontario, L8L 5G4
NOT_YET_RECRUITING
Name
Boehringer Ingelheim
Role
CONTACT
Phone:
18336022346
Saul Vizel Medicine Professional Corporation
Cambridge, Ontario, N1R 7R1
NOT_YET_RECRUITING
Name
Boehringer Ingelheim
Role
CONTACT
Phone:
18336022346

Quebec

Diex Recherche (Sherbrooke)
Sherbrooke, Quebec, J1L 0H8
NOT_YET_RECRUITING
Name
Boehringer Ingelheim
Role
CONTACT
Phone:
18336022346
Diex Recherche (Trois-Rivieres)
Trois-Rivières, Quebec, G9A 4P3
RECRUITING
Name
Boehringer Ingelheim
Role
CONTACT
Phone:
18336022346
Institut Universitaire de Cardiologie et de Pneumologie de Quebec (IUCPQ)
Québec, Quebec, G1V 4G5
NOT_YET_RECRUITING
Name
Boehringer Ingelheim
Role
CONTACT
Phone:
18336022346
ViaCar Recherches Cliniques Inc. (Brossard)
Brossard, Quebec, J4Z 2K9
RECRUITING
Name
Boehringer Ingelheim
Role
CONTACT
Phone:
18336022346
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