Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation

Last updated:
2026-09-26
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View trial details

Overview

Official protocol title:

A PILOT STUDY OF INTRATHECAL TOPOTECAN AND MAINTENANCE CHEMOTHERAPY IN THE POST-CONSOLIDATION SETTING FOR THE TREATMENT OF HIGH-RISK EMBRYONAL CENTRAL NERVOUS SYSTEM TUMOURS IN CHILDREN LESS THAN 6 YEARS OF AGE

Intervention/treatment:
TAMOXIFEN / ETOPOSIDE PHOSPHATE
Medical condition:
TUMOR
Protocol code:
DECRYPT-BABYBRAIN
Control number:
296309
Status:
Recruiting
Approved:
April 25, 2025
Trial phase:
Early phase 1
For more information:
ClinicalTrials.gov - NCT06942039
This is an external link. The information is not authorized by the Government of Canada.

Eligibility

Sex: ALL
Age
Birth to 6 Years
Accepts healthy volunteers: No

Contacts and locations

Contact
Name
Sylvia Cheng
Role
CONTACT
Phone:
416-813-7654
Extension 414839
Name
C17 Council
Role
CONTACT
Sponsor
C17 COUNCIL

Locations

Stollery Children's Hospital
Edmonton
RECRUITING
Name
Guru Piragasam
Role
CONTACT
Name
Liana Nobre
Role
PRINCIPAL_INVESTIGATOR
The Hospital for Sick Children
Toronto
RECRUITING
Name
Grace Silver
Role
CONTACT
Name
Anthony Liu
Role
PRINCIPAL_INVESTIGATOR

Alberta

Alberta Children's Hospital
Calgary, Alberta
RECRUITING
Name
Oluwatosin Ogunleye
Role
CONTACT
Name
Lucie Lafay-Cousin
Role
CONTACT
Name
Lucie Lafay-Cousin
Role
PRINCIPAL_INVESTIGATOR

British Columbia

BC Children's Hospital
Vancouver, British Columbia
RECRUITING
Name
Sofie Jensen
Role
CONTACT
Name
George Michaiel
Role
PRINCIPAL_INVESTIGATOR

Manitoba

CancerCare Manitoba (CCMB)
Winnipeg, Manitoba
RECRUITING
Name
Divya Subburaj, MD
Role
CONTACT
Phone:
204-787-4156
Name
Divya Subburaj
Role
PRINCIPAL_INVESTIGATOR

Nova Scotia

IWK Health Centre
Halifax, Nova Scotia
NOT_YET_RECRUITING
Name
Tiffany Rent
Role
CONTACT
Name
Bruce Crooks
Role
PRINCIPAL_INVESTIGATOR

Ontario

London Health Sciences Centre
London, Ontario
RECRUITING
Name
Jessica Kuzyk
Role
CONTACT
Name
Shayna Zelcer
Role
PRINCIPAL_INVESTIGATOR
McMaster Children's Hospital
Hamilton, Ontario
RECRUITING
Name
Shawde Campbell
Role
CONTACT
Name
Adam Fleming
Role
PRINCIPAL_INVESTIGATOR

Quebec

Centre hospitalier universitaire de Sherbrooke (CHUS)
Sherbrooke, Quebec
RECRUITING
Name
Alexis Gonneaud
Role
CONTACT
Name
Stephanie Vairy
Role
PRINCIPAL_INVESTIGATOR
CHU de Québec-Université Laval
Quebec, Quebec
RECRUITING
Name
Panagiota Giannakouros
Role
CONTACT
Name
Samuele Renzi
Role
PRINCIPAL_INVESTIGATOR
CHU Sainte-Justine
Montreal, Quebec
RECRUITING
Name
Caroline Tra
Role
CONTACT
Name
Sebastien Perreault
Role
PRINCIPAL_INVESTIGATOR
Montreal Children's Hospital (McGill)
Montreal, Quebec
NOT_YET_RECRUITING
Name
Poshia Boateng
Role
CONTACT
Name
Christina Coleman
Role
PRINCIPAL_INVESTIGATOR
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