A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

Last updated:
2026-08-29
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View trial details

Overview

Official protocol title:

A PHASE 3 RANDOMIZED, OPEN-LABEL, MULTICENTER STUDY TO COMPARE THE EFFICACY AND SAFETY OF SACITUZUMAB TIRUMOTECAN IN COMBINATION WITH PEMBROLIZUMAB VERSUS PEMBROLIZUMAB ALONE AS FIRST-LINE MAINTENANCE TREATMENT IN PARTICIPANTS WITH MISMATCH REPAIR PROFICIENT ENDOMETRIAL CANCER (TROFUSE-033/GOG-3119/ENGOT-EN29)

Intervention/treatment:
MK-2870 (SACITUZUMAB TIRUMOTECAN, SKB264) / KEYTRUDA / CARBOPLATIN / PACLITAXEL / DOCETAXEL
Medical condition:
ENDOMETRIAL CANCER
Protocol code:
MK-2870-033
Control number:
295786
Status:
Recruiting
Approved:
April 03, 2025
Trial phase:
Phase 3
For more information:
ClinicalTrials.gov - NCT06952504
This is an external link. The information is not authorized by the Government of Canada.

Eligibility

Sex: FEMALE
Age
18 Years and older
Accepts healthy volunteers: No

Contacts and locations

Contact
Name
Toll Free Number
Role
CONTACT
Phone:
1-888-577-8839
Sponsor
MERCK CANADA INC

Locations

British Columbia

BC Cancer Surrey ( Site 0621)
Surrey, British Columbia, V3V 1Z2
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
604-930-2098

Manitoba

CancerCare Manitoba ( Site 0617)
Winnipeg, Manitoba, R3E 0V9
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
204-787-4156

Newfoundland and Labrador

NL Health Services ( Site 0602)
St. John's, Newfoundland and Labrador, A1B 3V6
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
709-777-6300

Ontario

London Health Sciences Centre ( Site 0611)
London, Ontario, N6A 5W9
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
519-685-8500
Princess Margaret Cancer Center ( Site 0609)
Toronto, Ontario, M5G 2M9
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
416-946-4501
Royal Victoria Regional Health Centre ( Site 0615)
Barrie, Ontario, L4M 6M2
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
705 728-9090x66228
Sault Area Hospital ( Site 0616)
Sault Ste. Marie, Ontario, P6B 0A8
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
705-759-3434x4402
Sunnybrook Research Institute ( Site 0610)
Toronto, Ontario, M4N 3M5
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
416 480-6100
Windsor Regional Cancer Program ( Site 0614)
Windsor, Ontario, N8W 1L9
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
519-254-5577

Quebec

Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0605)
Montreal, Quebec, H2X 0C1
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
514-890-8000 x30777
CIUSSS de l'Est-de-l'Île-de-Montréal ( Site 0607)
Montreal, Quebec, H1T 2M4
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
514-252-3400 X5766
CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0608)
Sherbrooke, Quebec, J1H 5N4
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
8193461110x12890
Jewish General Hospital ( Site 0606)
Montreal, Quebec, H3T 1E2
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
514-340-8222
McGill University Health Centre ( Site 0604)
Montreal, Quebec, H4A 3J1
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
5145772241
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