A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

Last updated:
2026-08-22
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View trial details

Overview

Official protocol title:

A PHASE 3, RANDOMIZED, OPEN-LABEL STUDY COMPARING EFFICACY AND SAFETY OF SACITUZUMAB TIRUMOTECAN (SAC-TMT, MK-2870) AS A MONOTHERAPY AND IN COMBINATION WITH PEMBROLIZUMAB (MK-3475) VERSUS TREATMENT OF PHYSICIAN¿S CHOICE IN PARTICIPANTS WITH PREVIOUSLY UNTREATED LOCALLY RECURRENT UNRESECTABLE OR METASTATIC TRIPLE-NEGATIVE BREAST CANCER EXPRESSING PD-L1 AT CPS LESS THAN 10 (TROFUSE-011)

Intervention/treatment:
MK-2870 / KEYTRUDA
Medical condition:
BREAST CANCER
Protocol code:
MK-2870-011
Control number:
294264
Status:
Recruiting
Approved:
February 13, 2025
Trial phase:
Phase 3
For more information:
ClinicalTrials.gov - NCT06841354
This is an external link. The information is not authorized by the Government of Canada.

Eligibility

Sex: ALL
Age
18 Years and older
Accepts healthy volunteers: No

Contacts and locations

Contact
Name
Toll Free Number
Role
CONTACT
Phone:
1-888-577-8839
Sponsor
MERCK CANADA INC

Locations

Alberta

Cross Cancer Institute ( Site 0216)
Edmonton, Alberta, T6G 1Z2
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
7804328644

Ontario

Lakeridge Health ( Site 0217)
Oshawa, Ontario, L1G 2B9
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
905-576-8711
North York General Hospital ( Site 0209)
Toronto, Ontario, M2K 1E1
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
416-756-6000
Princess Margaret Cancer Centre ( Site 0202)
Toronto, Ontario, M5G 2M9
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
416-946-2000

Quebec

Centre Hospitalier de l'Université de Montréal ( Site 0208)
Montreal, Quebec, H2X 3E4
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
514-890-8444
CIUSSS- saguenay-Lac-Saint-Jean ( Site 0213)
Chicoutimi, Quebec, G7H 5H6
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
418-541-1000
Hopital Du Saint-Sacrement ( Site 0210)
Québec, Quebec, G1S 4L8
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
4186827511
Jewish General Hospital ( Site 0203)
Montreal, Quebec, H3T 1E2
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
514-340-8222
McGill University Health Centre ( Site 0204)
Montreal, Quebec, H4A 3J1
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
514-299-6425
St. Marys Hospital Center ( Site 0201)
Montreal, Quebec, H3T 1M5
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
514-891-6904

Saskatchewan

Saskatoon Cancer Centre ( Site 0215)
Saskatoon, Saskatchewan, S7N 4H4
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
306-655-2662
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