Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)

Last updated:
2026-08-15
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View trial details

Overview

Official protocol title:

A PHASE 3, RANDOMIZED, OPEN-LABEL, STUDY TO COMPARE THE EFFICACY AND SAFETY OF ADJUVANT MK-2870 IN COMBINATION WITH PEMBROLIZUMAB (MK- 3475) VERSUS TREATMENT OF PHYSICIAN¿S CHOICE (TPC) IN PARTICIPANTS WITH TRIPLE-NEGATIVE BREAST CANCER (TNBC) WHO RECEIVED NEOADJUVANT THERAPY AND DID NOT ACHIEVE A PATHOLOGICAL COMPLETE RESPONSE (PCR) AT SURGERY

Intervention/treatment:
MK-2870 (SKB264) / MK-3475 (PEMBROLIZUMAB) / CAPECITABINE
Medical condition:
BREAST CANCER
Protocol code:
MK-2870-012
Control number:
284691
Status:
Recruiting
Approved:
April 04, 2024
Trial phase:
Phase 3
For more information:
ClinicalTrials.gov - NCT06393374
This is an external link. The information is not authorized by the Government of Canada.

Eligibility

Sex: ALL
Age
18 Years and older
Accepts healthy volunteers: No

Contacts and locations

Contact
Name
Toll Free Number
Role
CONTACT
Phone:
1-888-577-8839
Sponsor
MERCK CANADA INC

Locations

Alberta

Cross Cancer Institute ( Site 0407)
Edmonton, Alberta, T6G 1Z2
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
7804328956

British Columbia

BC Cancer Vancouver ( Site 0404)
Vancouver, British Columbia, V5Z 4E6
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
6048776000

Manitoba

CancerCare Manitoba ( Site 0411)
Winnipeg, Manitoba, R2H 2A6
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
2047872127

New Brunswick

The Moncton Hospital ( Site 0401)
Moncton, New Brunswick, E1C 6Z8
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
5068575756

Nova Scotia

QEII Health Sciences Centre - Victoria General Site ( Site 0418)
Halifax, Nova Scotia, B3H 2Y9
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
9024732160

Ontario

Kingston Health Sciences Centre-Kingston General Hospital Site ( Site 0422)
Kingston, Ontario, K7L 2V7
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
613-549-6666
North York General Hospital ( Site 0415)
Toronto, Ontario, M2K 1E1
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
4167566000
Princess Margaret Cancer Centre ( Site 0400)
Toronto, Ontario, M5G 2M9
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
4169464501x2245
Southlake Health ( Site 0413)
Newmarket, Ontario, L3Y 2P9
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
9058954521x5155
The Ottawa Hospital - General Campus ( Site 0414)
Ottawa, Ontario, K1H 8L6
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
6137377700x70208

Quebec

Centre Hospitalier de l'Université de Montréal ( Site 0403)
Montreal, Quebec, H2X 3E4
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
5148908000
Centre integre universitaire de sante et de services sociaux de la Mauricie-et-du-centre-du-quebec ( Site 0406)
Trois-Rivières, Quebec, G8Z 3R9
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
8196973333x63238
Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre ( Site 0417)
Greenfield Park, Quebec, J4V 2H1
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
4504665000x3226
Centre intégré de santé et de services sociaux du Bas Saint-Laurent- Hôpital régional de Rimouski ( Site 0409)
Rimouski, Quebec, G5L 5T1
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
4187243000x8029
CIUSSS de l'Est-de-l'Île-de-Montréal ( Site 0419)
Montreal, Quebec, H1T 2M4
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
5142523400x6244
Jewish General Hospital ( Site 0416)
Montreal, Quebec, H3T 1E2
Recruiting
Name
Study Coordinator
Role
CONTACT
Phone:
5143405222x27562
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