Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

Last updated:
2026-07-18
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View trial details

Overview

Official protocol title:

OPTIMICE-PCR: DE-ESCALATION OF THERAPY IN EARLY-STAGE TNBC PATIENTS WHO ACHIEVE PCR AFTER NEOADJUVANT CHEMOTHERAPY WITH CHECKPOINT INHIBITOR THERAPY

Intervention/treatment:
KEYTRUDA
Medical condition:
BREAST CANCER TRIPLE NEGATIVE
Protocol code:
MAC.29 / A012103
Control number:
284407
Status:
Recruiting
Approved:
March 27, 2024
Trial phase:
Phase 3
For more information:
ClinicalTrials.gov - NCT05812807
This is an external link. The information is not authorized by the Government of Canada.

Eligibility

Sex: ALL
Age
18 Years and older
Accepts healthy volunteers: No

Contacts and locations

Contact
Name
Sara Tolaney, MD
Role
CONTACT
Phone:
617-632-2335
Name
Laura Hoffman
Role
CONTACT
Phone:
773-834-2546
Sponsor
CANADIAN CANCER TRIALS GROUP, CANCER RESEARCH INSTITUTE, QUEEN'S UNIVERSITY

Locations

British Columbia

BCCA-Cancer Centre for the Southern Interior
Kelowna, British Columbia, V1Y 5L3
Recruiting
Name
Site Public Contact
Role
CONTACT
Phone:
250-712-3900
Name
Sara K. Taylor
Role
PRINCIPAL_INVESTIGATOR
BCCA-Vancouver Cancer Centre
Vancouver, British Columbia, V5Z 4E6
Recruiting
Name
Site Public Contact
Role
CONTACT
Phone:
888-939-3333
Name
Stephen K. Chia
Role
PRINCIPAL_INVESTIGATOR

New Brunswick

Atlantic Health Sciences Corporation-Saint John Regional Hospital
Saint John, New Brunswick, E2L 4L2
Recruiting
Name
Site Public Contact
Role
CONTACT
Phone:
506-648-6890
Name
Amy Groom
Role
PRINCIPAL_INVESTIGATOR

Ontario

Cambridge Memorial Hospital
Cambridge, Ontario, N1R 3G2
Recruiting
Name
Site Public Contact
Role
CONTACT
Phone:
519-621-2333
Name
Skander Ghedira
Role
PRINCIPAL_INVESTIGATOR
Kingston Health Sciences Centre
Kingston, Ontario, K7L 2V7
Recruiting
Name
Site Public Contact
Role
CONTACT
Phone:
613-549-6666
Name
Brooke E. Wilson
Role
PRINCIPAL_INVESTIGATOR
London Regional Cancer Program
London, Ontario, N6A 4L6
Recruiting
Name
Site Public Contact
Role
CONTACT
Phone:
519-685-8600
Name
Hamid Mithoowani
Role
PRINCIPAL_INVESTIGATOR
Odette Cancer Centre- Sunnybrook Health Sciences Centre
Toronto, Ontario, M4N 3M5
Recruiting
Name
Site Public Contact
Role
CONTACT
Phone:
416-480-5000
Name
Katarzyna (Kasia) J. Jerzak
Role
PRINCIPAL_INVESTIGATOR
Ottawa Hospital and Cancer Center-General Campus
Ottawa, Ontario, K1H 8L6
Recruiting
Name
Site Public Contact
Role
CONTACT
Phone:
613-761-4395
Name
Sharon McGee
Role
PRINCIPAL_INVESTIGATOR
University Health Network-Princess Margaret Hospital
Toronto, Ontario, M5G 2M9
Recruiting
Name
Site Public Contact
Role
CONTACT
Phone:
416-946-4501
Name
David W. Cescon
Role
PRINCIPAL_INVESTIGATOR

Quebec

Centre Hospitalier Regional de Trois-Rivieres
Trois-Rivières, Quebec, G8Z 3R9
Recruiting
Name
Site Public Contact
Role
CONTACT
Phone:
819-697-3333
Extension 64399
Name
Anouk Tremblay
Role
PRINCIPAL_INVESTIGATOR
CHU de Quebec-Hopital du Saint-Sacrement (HSS)
Québec, Quebec, G1S 4L8
Recruiting
Name
Site Public Contact
Role
CONTACT
Phone:
418-649-5593
Name
Claudya Morin
Role
PRINCIPAL_INVESTIGATOR
Jewish General Hospital
Montreal, Quebec, H3T 1E2
Recruiting
Name
Site Public Contact
Role
CONTACT
Phone:
514-340-8222
Extension 8248
Name
Jennifer Friedmann
Role
PRINCIPAL_INVESTIGATOR

Saskatchewan

Allan Blair Cancer Centre
Regina, Saskatchewan, S4T 7T1
Recruiting
Name
Site Public Contact
Role
CONTACT
Phone:
306-766-2213
Name
Muhammad H. Khan
Role
PRINCIPAL_INVESTIGATOR
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, S7N 4H4
Recruiting
Name
Site Public Contact
Role
CONTACT
Phone:
306-655-2914
Name
Shahid Ahmed
Role
PRINCIPAL_INVESTIGATOR
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