Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations

Last updated:
2026-07-18
Language and content disclaimer

The content and search results on this site are collected from or provided by third parties. As such some of the information may only be available in the language originally submitted by the sponsor of the trial. Learn more about the information on the search portal.

Linking to Non-Government of Canada Websites

Links to websites not under the control of the Government of Canada, including those to our social media accounts, and to clinical trial records in international registries are provided solely for the convenience of our website visitors. We are not responsible for the accuracy, currency or reliability of the content of such websites. The Government of Canada does not offer any guarantee in that regard and is not responsible for the information found through these links, nor does it endorse the sites and their content.

Visitors should also be aware that information offered by non-Government of Canada sites to which this website links is not subject to the Privacy Act or the Official Languages Act and may not be accessible to persons with disabilities. The information offered may be available only in the language(s) used by the sites in question. With respect to privacy, visitors should research the privacy policies of these non-government websites before providing personal information.

View trial details

Overview

Official protocol title:

A PHASE III, RANDOMISED, OPEN-LABEL, GLOBAL STUDY OF DATOPOTAMAB DERUXTECAN (DATO-DXD) IN COMBINATION WITH RILVEGOSTOMIG (AZD2936) OR RILVEGOSTOMIG MONOTHERAPY VERSUS PEMBROLIZUMAB MONOTHERAPY FOR THE FIRST-LINE TREATMENT OF PARTICIPANTS WITH LOCALLY-ADVANCED OR METASTATIC NON-SQUAMOUS NSCLC WITH HIGH PD-L1 EXPRESSION (TC ¿ 50%) AND WITHOUT ACTIONABLE GENOMIC ALTERATIONS (TROPION-LUNG10)

Intervention/treatment:
DATOPOTAMAB DERUXTECAN (DATO-DXD) / RILVEGOSTOMIG (AZD2936)
Medical condition:
NON-SQUAMOUS/SQUAMOUS NSCLC
Protocol code:
D7632C00001
Control number:
281062
Status:
Recruiting
Approved:
December 13, 2023
Trial phase:
Phase 3
For more information:
ClinicalTrials.gov - NCT06357533
This is an external link. The information is not authorized by the Government of Canada.

Eligibility

Sex: ALL
Age
18 Years and older
Accepts healthy volunteers: No

Contacts and locations

Contact
Name
AstraZeneca Clinical Study Information Center
Role
CONTACT
Phone:
1-877-240-9479
Sponsor
ASTRAZENECA CANADA INC

Locations

British Columbia

Research Site
Vancouver, British Columbia, VSZ 4E6
RECRUITING

Manitoba

Research Site
Winnipeg, Manitoba, R3E 0V9
WITHDRAWN

Newfoundland and Labrador

Research Site
St. John's, Newfoundland and Labrador, A1B 3V6
RECRUITING

Ontario

Research Site
London, Ontario, N6A 4L6
RECRUITING
Research Site
Newmarket, Ontario, L3Y 2P9
WITHDRAWN
Research Site
Oshawa, Ontario, L1G 2B9
RECRUITING
Research Site
Toronto, Ontario, M4N 3M5
WITHDRAWN

Quebec

Research Site
Lévis, Quebec, G6V 0B8
RECRUITING
Research Site
Montreal, Quebec, H3T 1E2
RECRUITING
Research Site
Montreal, Quebec, H3T 1M5
RECRUITING
Research Site
Montreal, Quebec, H4J 1C5
RECRUITING
Research Site
Rimouski, Quebec, G5L 5T1
RECRUITING
Research Site
Trois-Rivières, Quebec, G8Z 3R9
RECRUITING
Research Site
Chicoutimi, Quebec, G7H 5H6
RECRUITING

Saskatchewan

Research Site
Saskatoon, Saskatchewan, S7N 4H4
RECRUITING
Did you find what you were looking for?