Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy

Last updated:
2026-07-18
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View trial details

Overview

Official protocol title:

TARGETED THERAPY WITH GLYCOGEN SYNTHASE KINASE-3 INHIBITION FOR ARRHYTHMOGENIC CARDIOMYOPATHY (TARGET)

Intervention/treatment:
TIDEGLUSIB
Medical condition:
CARDIOMYOPATHY
Protocol code:
PHRI.TARGET
Control number:
279403
Status:
Recruiting
Approved:
October 31, 2023
Trial phase:
Phase 2
For more information:
ClinicalTrials.gov - NCT06174220
This is an external link. The information is not authorized by the Government of Canada.

Eligibility

Sex: ALL
Age
18 Years and older
Accepts healthy volunteers: No

Contacts and locations

Contact
Name
Jason Roberts, MD MAS
Role
CONTACT
Phone:
905-521-2100
Extension 40354
Name
Maha Mushtaha
Role
CONTACT
Sponsor
HAMILTON HEALTH SCIENCES CORPORATION

Locations

Alberta

University of Calgary
Calgary, Alberta, T2N 2T9
RECRUITING
Name
Erkan Ilhan
Role
CONTACT
Phone:
403-210-6047
Name
Erkan Ilhan, MD
Role
PRINCIPAL_INVESTIGATOR
Name
Patrick Champagne, MD
Role
SUB_INVESTIGATOR

British Columbia

University of British Columbia
Vancouver, British Columbia, V6Z 1Y6
RECRUITING
Name
Thomas Roston
Role
CONTACT
Phone:
604-682-2344
Extension 66863
Name
Thomas M Roston, MD PhD
Role
PRINCIPAL_INVESTIGATOR
Name
Zachary Laksman, MD MSc
Role
PRINCIPAL_INVESTIGATOR
Name
Andrew D Krahn, MD
Role
PRINCIPAL_INVESTIGATOR
Name
Gnalini Sathananthan, MD
Role
SUB_INVESTIGATOR
Victoria Cardiac Arrhythmia Trials Inc.
Victoria, British Columbia, V8Z 0B9
RECRUITING
Name
May Woodburn
Role
CONTACT
Phone:
250-595-0400
Name
Martin van Zyl, MD
Role
PRINCIPAL_INVESTIGATOR
Name
Karan Shetty, MD
Role
SUB_INVESTIGATOR

Newfoundland and Labrador

NL Health Services
St. John's, Newfoundland and Labrador, A1B 3V6
RECRUITING
Name
Stephen Duffett
Role
CONTACT
Phone:
709-752-4636
Name
Stephen Duffett, MD
Role
PRINCIPAL_INVESTIGATOR
Name
Sean Connors, MD
Role
PRINCIPAL_INVESTIGATOR
Name
Kathy Hodgkinson, PhD
Role
PRINCIPAL_INVESTIGATOR
Name
Ashar Pirzada, MD
Role
SUB_INVESTIGATOR

Nova Scotia

Nova Scotia Health
Halifax, Nova Scotia, B3H 2Y9
RECRUITING
Name
Victoria Newman
Role
CONTACT
Phone:
902-473-5341
Name
David Lee, MD
Role
PRINCIPAL_INVESTIGATOR
Name
Ciorsti MacIntyre, MD
Role
PRINCIPAL_INVESTIGATOR
Name
Daniel Belliveau, MD
Role
SUB_INVESTIGATOR

Ontario

Hamilton General Hospital
Hamilton, Ontario, L8L 2X2
RECRUITING
Name
Jeff Healey
Role
CONTACT
Phone:
905-527-0271
Extension 40312
Name
Jeff S Healey, MD
Role
PRINCIPAL_INVESTIGATOR
Name
Javier Ganame, MD
Role
SUB_INVESTIGATOR
Name
William F McIntyre, MD PhD FRCPC
Role
SUB_INVESTIGATOR
Heart Health Institute Research Inc
Scarborough Village, Ontario, M1E 4B9
RECRUITING
Name
Emily Magimaidoss
Role
CONTACT
Phone:
416-281-9499
Extension 3015
Name
Bhavanesh Makanjee, MD
Role
PRINCIPAL_INVESTIGATOR
Name
Derek Yung, MD
Role
PRINCIPAL_INVESTIGATOR
Name
Natalie Ho, MD
Role
SUB_INVESTIGATOR
Kingston General Hospital
Kingston, Ontario, K7L 2V7
NOT_YET_RECRUITING
Name
Chris Simpson, MD
Role
PRINCIPAL_INVESTIGATOR
Name
Amar Thakrar, MD
Role
SUB_INVESTIGATOR
London Health Sciences Centre
London, Ontario, N6A 5A5
RECRUITING
Name
Sara El-Richani
Role
CONTACT
Phone:
519-685-8500
Extension 36808
Name
Habib R Khan, MD
Role
PRINCIPAL_INVESTIGATOR
Newmarket Electrophysiologist Research Group 'NERG'
Newmarket, Ontario, L3Y 2P9
NOT_YET_RECRUITING
Name
Mouhannad Sadek, MD
Role
PRINCIPAL_INVESTIGATOR
Name
Molly Thangaroopan, MD
Role
SUB_INVESTIGATOR
St. Michael's Hospital
Toronto, Ontario, M5B 1W8
NOT_YET_RECRUITING
Name
Paul Angaran, MD
Role
PRINCIPAL_INVESTIGATOR
Name
Geraldine Ong, MD
Role
SUB_INVESTIGATOR
Sunnybrook Health Sciences Centre
Toronto, Ontario, M4N 3M5
NOT_YET_RECRUITING
Name
Christopher Cheung, MD
Role
PRINCIPAL_INVESTIGATOR
Name
Idan Roifman, MD
Role
SUB_INVESTIGATOR
University of Ottawa Heart Institute
Ottawa, Ontario, K1Y 4W7
NOT_YET_RECRUITING
Name
Simon Hansom, MD
Role
PRINCIPAL_INVESTIGATOR
Name
Martin Green, MD
Role
PRINCIPAL_INVESTIGATOR
Name
Lawrence Lau, MD
Role
SUB_INVESTIGATOR

Quebec

Hopital du Sacré-Coeur de Montréal
Montreal, Quebec, H4J 1C5
NOT_YET_RECRUITING
Name
Leila Laroussi, MD
Role
PRINCIPAL_INVESTIGATOR
Name
Alexios Hadjis, MD
Role
PRINCIPAL_INVESTIGATOR
Name
Nadia Boule-Laghlazi, MD
Role
SUB_INVESTIGATOR
McGill University Health Centre
Montreal, Quebec, H4A 3J1
NOT_YET_RECRUITING
Name
Jacqueline Joza, MD
Role
PRINCIPAL_INVESTIGATOR
Name
Michael Chetrit, MD
Role
SUB_INVESTIGATOR
Montreal Heart Institute
Montreal, Quebec, H1T 1C8
RECRUITING
Name
Jeremie Cortial
Role
CONTACT
Phone:
514-376-3330
Extension 2293
Name
Julia Cadrin-Tourigny, MD PhD
Role
PRINCIPAL_INVESTIGATOR
Name
Rafik Tadros, MD PhD
Role
PRINCIPAL_INVESTIGATOR
Name
Marie Chaix, MD
Role
SUB_INVESTIGATOR
University Institute of Cardiology and Pneumology of Quebec
Québec, Quebec, G1V 4G5
RECRUITING
Name
Dr. Christian Steinberg
Role
CONTACT
Phone:
418-656-8711
Name
Christian Steinberg, MD
Role
PRINCIPAL_INVESTIGATOR
Name
Jonathan Beaudoin, MD
Role
SUB_INVESTIGATOR
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