An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)

Last updated:
2026-08-15
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View trial details

Overview

Official protocol title:

A PHASE III, OPEN-LABEL, RANDOMISED STUDY TO ASSESS THE EFFICACY AND SAFETY OF CAMIZESTRANT (AZD9833, A NEXT GENERATION, ORAL SELECTIVE ESTROGEN RECEPTOR DEGRADER) VERSUS STANDARD ENDOCRINE THERAPY (AROMATASE INHIBITOR OR TAMOXIFEN) AS ADJUVANT TREATMENT FOR PATIENTS WITH ER+/HER2- EARLY BREAST CANCER AND AN INTERMEDIATE- HIGH OR HIGH RISK OF RECURRENCE WHO HAVE COMPLETED DEFINITIVE LOCOREGIONAL TREATMENT AND HAVE NO EVIDENCE OF DISEASE

Intervention/treatment:
CAMIZESTRANT (AZD9833)
Medical condition:
BREAST CANCER
Protocol code:
D8535C00001
Control number:
276922
Status:
Active, not recruiting
Approved:
July 31, 2023
Trial phase:
Phase 3
For more information:
ClinicalTrials.gov - NCT05952557
This is an external link. The information is not authorized by the Government of Canada.

Eligibility

Sex: ALL
Age
18 Years to 130 Years
Accepts healthy volunteers: No

Contacts and locations

Contact
Name
AstraZeneca Clinical Study Information Center
Role
CONTACT
Phone:
1-877-240-9479
Name
AstraZeneca Breast Cancer Study Locator Service
Role
CONTACT
Phone:
1-877-400-4656
Sponsor
ASTRAZENECA AB

Locations

Alberta

Research Site
Calgary, Alberta, T2N 4N2
Recruiting
Research Site
Edmonton, Alberta, t6G1Z2
Recruiting

British Columbia

Research Site
Kelowna, British Columbia, V1Y 5L3
Recruiting
Research Site
North Vancouver, British Columbia, V7L 2L7
Active, not recruiting

Ontario

Research Site
Barrie, Ontario, L4M 6M2
WITHDRAWN
Research Site
Greater Sudbury, Ontario, P3E 5J1
Recruiting
Research Site
Kingston, Ontario, K7L 2V7
Recruiting
Research Site
Thunder Bay, Ontario, P7B 6V4
Recruiting

Quebec

Research Site
Chicoutimi, Quebec, G7H 5H6
WITHDRAWN
Research Site
Lévis, Quebec, G6V 3Z1
Recruiting
Research Site
Montreal, Quebec, H1T 2M4
WITHDRAWN
Research Site
Montreal, Quebec, H2X 3E4
Recruiting
Research Site
Montreal, Quebec, H4A 3J1
Recruiting
Research Site
Québec, Quebec, G1S 4L8
Recruiting

Saskatchewan

Research Site
Saskatoon, Saskatchewan, S7N 4H4
Recruiting
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