A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma

Last updated:
2026-07-25
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View trial details

Overview

Official protocol title:

A FEASIBILITY AND RANDOMIZED PHASE 2/3 STUDY OF THE VEFGR2/MET INHIBITOR CABOZANTINIB IN COMBINATION WITH CYTOTOXIC CHEMOTHERAPY FOR NEWLY DIAGNOSED OSTEOSARCOMA

Intervention/treatment:
CABOZANTINIB
Medical condition:
OSTEOSARCOMA
Protocol code:
AOST2032
Control number:
276782
Status:
Recruiting
Approved:
July 31, 2023
Trial phase:
Phase 2, Phase 3
For more information:
ClinicalTrials.gov - NCT05691478
This is an external link. The information is not authorized by the Government of Canada.

Eligibility

Sex: ALL
Age
Birth to 40 Years
Accepts healthy volunteers: No

Contacts and locations

Contact
Sponsor
CHILDRENS ONCOLOGY GROUP

Locations

CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)
Québec, G1V 4G2
RECRUITING
Name
Site Public Contact
Role
CONTACT
Phone:
418-525-4444
Name
Bruno Michon
Role
PRINCIPAL_INVESTIGATOR

Alberta

Alberta Children's Hospital
Calgary, Alberta, T3B 6A8
RECRUITING
Name
Site Public Contact
Role
CONTACT
Phone:
403-220-6898
Name
Victor A. Lewis
Role
PRINCIPAL_INVESTIGATOR
University of Alberta Hospital
Edmonton, Alberta, T6G 2B7
RECRUITING
Name
Site Public Contact
Role
CONTACT
Phone:
780-407-8798
Name
Sarah J. McKillop
Role
PRINCIPAL_INVESTIGATOR

Manitoba

CancerCare Manitoba
Winnipeg, Manitoba, R3E 0V9
RECRUITING
Name
Site Public Contact
Role
CONTACT
Phone:
866-561-1026
Name
Stephanie M. Villeneuve
Role
PRINCIPAL_INVESTIGATOR

Nova Scotia

IWK Health Centre
Halifax, Nova Scotia, B3K 6R8
RECRUITING
Name
Site Public Contact
Role
CONTACT
Phone:
902-470-8520
Name
Chelsea Ash
Role
PRINCIPAL_INVESTIGATOR

Ontario

Children's Hospital
London, Ontario, N6A 5W9
RECRUITING
Name
Site Public Contact
Role
CONTACT
Phone:
519-685-8306
Name
Shayna M. Zelcer
Role
PRINCIPAL_INVESTIGATOR
Children's Hospital of Eastern Ontario
Ottawa, Ontario, K1H 8L1
RECRUITING
Name
Site Public Contact
Role
CONTACT
Phone:
613-737-7600
Name
Donna L. Johnston
Role
PRINCIPAL_INVESTIGATOR
Hospital for Sick Children
Toronto, Ontario, M5G 1X8
RECRUITING
Name
Site Public Contact
Role
CONTACT
Phone:
416-813-7654
Name
Sarah A. Cohen-Gogo
Role
PRINCIPAL_INVESTIGATOR

Quebec

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Sherbrooke, Quebec, J1H 5N4
RECRUITING
Name
Site Public Contact
Role
CONTACT
Phone:
819-820-6480
Name
Josee Brossard
Role
PRINCIPAL_INVESTIGATOR
Centre Hospitalier Universitaire Sainte-Justine
Montreal, Quebec, H3T 1C5
RECRUITING
Name
Site Public Contact
Role
CONTACT
Phone:
514-345-4931
Name
Monia Marzouki
Role
PRINCIPAL_INVESTIGATOR
The Montreal Children's Hospital of the MUHC
Montreal, Quebec, H3H 1P3
RECRUITING
Name
Site Public Contact
Role
CONTACT
Phone:
514-412-4445
Name
Stephanie Mourad
Role
PRINCIPAL_INVESTIGATOR

Saskatchewan

Jim Pattison Children's Hospital
Saskatoon, Saskatchewan, S7N 0W8
RECRUITING
Name
Site Public Contact
Role
CONTACT
Phone:
306-655-3544
Name
Kathleen Felton
Role
PRINCIPAL_INVESTIGATOR
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