Liquid-biopsy Informed Platform Trial to Evaluate CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast Cancer

Last updated:
2026-07-18
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View trial details

Overview

Official protocol title:

A LIQUID-BIOPSY INFORMED PLATFORM TRIAL TO EVALUATE TREATMENT IN CDK4/6-INHIBITOR RESISTANT ER+/HER2- METASTATIC BREAST CANCER

Intervention/treatment:
NIRAPARIB / CFI-400945 / CFI-402257 / SACITUZUMAB GOVITECAN
Medical condition:
ER+/HER2-BREAST CANCER
Protocol code:
IND.241
Control number:
268543
Status:
Recruiting
Approved:
November 14, 2022
Trial phase:
Phase 2
For more information:
ClinicalTrials.gov - NCT05601440
This is an external link. The information is not authorized by the Government of Canada.

Eligibility

Sex: ALL
Age
Accepts healthy volunteers: No

Contacts and locations

Contact
Name
Lesley Seymour
Role
CONTACT
Phone:
613-533-6430
Name
Laura Pearce
Role
CONTACT
Phone:
613-533-6430
Sponsor
CANADIAN CANCER TRIALS GROUP, CANCER RESEARCH INSTITUTE, QUEEN'S UNIVERSITY

Locations

Alberta

Arthur J.E. Child Comprehensive Cancer Centre
Calgary, Alberta, T2N 5G2
Recruiting
Name
Patricia Tang
Role
CONTACT
Phone:
403 521-3490

British Columbia

BCCA - Kelowna
Kelowna, British Columbia, V1Y 5L3
Recruiting
Name
Sara Kristina Taylor
Role
CONTACT
Phone:
250 712-3996
BCCA - Vancouver
Vancouver, British Columbia, V5Z 4E6
Recruiting
Name
Nathalie Levasseur
Role
CONTACT
Phone:
604 877-6000

Nova Scotia

QEII Health Sciences Centre
Halifax, Nova Scotia, B3H 1V7
Recruiting
Name
Daniel Rayson
Role
CONTACT
Phone:
902 473-6106

Ontario

Juravinski Cancer Centre at Hamilton Health Sciences
Hamilton, Ontario, L8V 5C2
Recruiting
Name
Nidhi Kumar Tyagi
Role
CONTACT
Phone:
905 387-9495
Kingston Health Sciences Centre
Kingston, Ontario, K7L 2V7
Recruiting
Name
Brooke Wilson
Role
CONTACT
Odette Cancer Centre
Toronto, Ontario, M4N 3M5
On hold
Ottawa Hospital Research Institute
Ottawa, Ontario, K1H 8L6
Recruiting
Name
Moira Rushton
Role
CONTACT
University Health Network
Toronto, Ontario, M5G 2M9
Recruiting
Name
David Cescon
Role
CONTACT
Phone:
416 946-2245

Quebec

The Jewish General Hospital
Montreal, Quebec, H3T 1E2
Recruiting
Name
Parvaneh Fallah
Role
CONTACT
Phone:
614 340-8222
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