A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035)
Last updated:
Last updated
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2026-07-18
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A PIVOTAL PHASE 3 RANDOMIZED, PLACEBO-CONTROLLED CLINICAL STUDY TO EVALUATE THE EFFICACY AND SAFETY OF THE SGC STIMULATOR VERICIGUAT/MK-1242 IN ADULTS WITH CHRONIC HEART FAILURE WITH REDUCED EJECTION FRACTION
Intervention/treatment:
Intervention/treatment
Name given to the drug used in the clinical trial. This may be a code name, a chemical name of the active ingredient, a non-proprietary name or brand name.
VERICIGUAT (MK-1242; BAY 1021189)
Medical condition:
Medical condition
The disease or condition that's being studied in the clinical trial.
CHRONIC HEART FAILURE
Protocol code:
Protocol Code
An alpha-numeric sequence generated by the sponsor that can vary in length. Used as a reference to help identify a specific clinical trial protocol. Formerly referred to as 'protocol number'.
MK-1242-035
Control number:
Control number
A unique 6-digit identification number Health Canada assigns to each clinical trial application.
256388
Status:
Trial Status
The status for the clinical trial as a whole. Note that the status for each site may be different and should always be confirmed with the clinical trial sponsor. Health Canada uses information provided by the sponsor to an international clinical trial registry to determine status values for each clinical trial. Status values on the portal can include:
• Not yet recruiting - Participants are not yet being recruited or enrolled at any site. • Recruiting - Participants are currently being recruited. • Active, not recruiting - The clinical trial is ongoing but new participants are not currently being recruited or enrolled. • On hold - The clinical trial has been temporarily stopped, but it may start again. • Closed - The clinical trial has either ended normally and participants are no longer being examined or treated, or it has stopped early and will not start again. • Unknown - The status of the clinical trial has not been verified in the registry in the last 2 years. Please contact the sponsor. • No match, ongoing - Please contact sponsor for status information. • Other - Please contact sponsor for status information.
Closed
Approved:
Approved
The date that the clinical trial has been determined to meet Health Canada’s regulatory requirements. For drug clinical trials, this means that a no objection letter or an authorization was issued.
October 01, 2021
Date Completed:
Date completed
The date of the last participant’s last visit in the global study. The completion date may be actual or estimated, depending what was provided to the registry. Estimated completion dates may be in the past or future.
Trial phase:
Trial phase
The stage of a clinical trial, based on factors such as the objectives of the trial and number of participants. Phase data displayed in the portal is taken from international registry data.
For more information see "Phases of drug trials" on the Definitions webpage
This is an external link. The information is not authorized by the Government of Canada.
Eligibility
Eligibility
The characteristics people must have or the requirements they must meet to participate in the clinical trial. Eligibility criteria include both inclusion criteria (must have for a person to participate) and exclusion criteria (prevent a person from participating).
Review the exact criteria from the registry or the sponsor before making a decision to participate. The following values may be available on the portal:
Sex: an eligibility criteria based on biological characteristics. Information in the portal is based on available data and will default to 'all' when no other data is available.
Age: The age a person must be to participate in the clinical trial.
Accepts Healthy Volunteers: People who do not have the disease or condition can participate in the clinical trial.
Sex:
ALL
Age
18 Years and older
Accepts healthy volunteers:
No
Contacts and locations
Contact
Contact
Information for an individual or organisation that can respond to questions about this clinical trial. This information comes from the international registry.
Name
Senior Vice President, Global Clinical Development
The sponsor conducts the clinical trial and is responsible for every aspect. For example this could be a company, a university or an individual researcher.
MERCK CANADA INC
Locations
Alberta
Heritage Medical Research Clinic ( Site 0679)
Calgary, Alberta, T2N 4Z6
University Of Alberta Hospital ( Site 0669)
Edmonton, Alberta, T6G 2B7
British Columbia
Victoria Heart Institute Foundation ( Site 0680)
Victoria, British Columbia, V8R 1B2
Manitoba
St. Boniface General Hospital ( Site 0667)
Winnipeg, Manitoba, R2H 2A6
New Brunswick
G A Research Associates ( Site 0652)
Moncton, New Brunswick, E1G 1A7
Nova Scotia
NSHA-QEII Health Sciences Centre-Dickson Bldg-Cardiology ( Site 0664)
Halifax, Nova Scotia, B3H 3A7
Ontario
Cambridge Cardiac Care Centre ( Site 0658)
Cambridge, Ontario, N1R 6V6
Corcare-Corcare Cardiovascular Research ( Site 0660)
Toronto, Ontario, M1B 5N1
Kawartha Cardiology Clinical Trials ( Site 0654)
Peterborough, Ontario, K9J 0B2
Medicus MFC Research Clinic ( Site 0676)
Toronto, Ontario, M4P 1E4
North York Diagnostic and Cardiac Centre ( Site 0682)
North York, Ontario, M6B 3H7
Oakville Cardiovascular Research LP ( Site 0657)
Oakville, Ontario, L6K 3W7
PACE Cardiology ( Site 0675)
Newmarket, Ontario, L3Y 2P6
Private Practice - Dr. James Cha ( Site 0655)
Oshawa, Ontario, L1J 2K1
Quebec
Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer
Sherbrooke, Quebec, J1H 5N4
Diex Recherche Trois-Rivieres ( Site 0677)
Trois-Rivières, Quebec, G9A 4P3
Hopital Pierre-Le Gardeur ( Site 0674)
Terrebonne, Quebec, J6V 2H2
Hôpital de la Cité-de-la-Santé ( Site 0673)
Laval, Quebec, H7M 3L9
Institut de Cardiologie de Montreal ( Site 0661)
Montreal, Quebec, H1T 1C8
Montreal General Hospital ( Site 0653)
Montreal, Quebec, H3G 1A4
Unité de Recherche Clinique du CISSS des Laurentides ( Site 0668)
