Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke

Last updated:
2026-07-11
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View trial details

Overview

Official protocol title:

A DOUBLE-BLIND, RANDOMIZED, PLACEBO CONTROLLED, MULTICENTER STUDY TO EVALUATE THE IMPACT OF EVOLOCUMAB ON MAJOR CARDIOVASCULAR EVENTS IN PATIENTS AT HIGH CARDIOVASCULAR RISK WITHOUT PRIOR MYOCARDIAL INFARCTION OR STROKE

Intervention/treatment:
REPATHA
Medical condition:
MAJOR CARDIOVASCULAR EVENTS
Protocol code:
20170625
Control number:
225866
Status:
Closed
Approved:
April 17, 2019
Date Completed:
Trial phase:
Phase 3
For more information:
ClinicalTrials.gov - NCT03872401
This is an external link. The information is not authorized by the Government of Canada.

Eligibility

Sex: ALL
Age
50 Years to 79 Years
Accepts healthy volunteers: No

Contacts and locations

Contact
Name
Study Director
Organization
Amgen Inc.
Phone:
866-572-6436
Sponsor
AMGEN CANADA INC

Locations

Alberta

LMC Clinical Research Incorporated
Calgary, Alberta, T2H 2G4

British Columbia

Dr T G Elliott Incorporated - BC Diabetes
Vancouver, British Columbia, V5Y 3W2
SMH Cardiology Clinical Trials Incorporated
Surrey, British Columbia, V3V 0C6

Manitoba

Winnipeg Clinic
Winnipeg, Manitoba, R3C 0N2

New Brunswick

G A Research Associates Limited
Moncton, New Brunswick, E1G 1A7

Newfoundland and Labrador

Commonwealth Medical Clinic
Mount Pearl, Newfoundland and Labrador, A1N 1W7

Nova Scotia

Queen Elizabeth II Health Sciences Centre, Halifax Infirmary
Halifax, Nova Scotia, B3H 3A7

Ontario

Bluewater Clinical Research Group Incorporated
Sarnia, Ontario, N7T 4X3
Brampton Clinical Trials
Brampton, Ontario, L6Z 4N5
Corcare Cardiovascular Research
Scarborough Village, Ontario, M1B 5N1
Dr James Cha
Oshawa, Ontario, L1J 2K1
Hamilton Health Sciences Hamilton General Hospital
Hamilton, Ontario, L8L 2X2
Heart Health Institute
Ajax, Ontario, L1Z 0B1
Heart Health Institute Research Incorporated
Scarborough Village, Ontario, M1B 4Z8
Kawartha Cardiology Clinical Trials
Peterborough, Ontario, K9J 0B2
LMC Clinical Research Incorporated
Barrie, Ontario, L4N 7L3
LMC Clinical Research Incorporated
Brampton, Ontario, L6S 0C6
LMC Clinical Research Incorporated
Etobicoke, Ontario, M9R 4E1
LMC Clinical Research Incorporated
Nepean, Ontario, K2J 0V2
LMC Clinical Research Incorporated Thornhill
Concord, Ontario, L4K 4M2
My Endo Diabetes and Endocrinology Center
Markham, Ontario, L3P 7P2
North York Diagnostic and Cardiac Centre
Toronto, Ontario, M6B 3H7
Oakville Cardiovascular Research
Oakville, Ontario, L6K 3W7
Office of Dr Louis Yao
Weston, Ontario, M9N 1W4
Partners in Advanced Cardiac Evaluation
Newmarket, Ontario, L3Y 2P6
SKDS Research Incorporated
Newmarket, Ontario, L3Y 5G8
Western Centre for Public Health and Family Medicine - Western University
London, Ontario, N6G 2M1
Womens College Hospital
Toronto, Ontario, M5S 1B2

Quebec

Applied Medical Informatics Research Incorporated
Montreal, Quebec, H4A 3T2
Centre intégré de santé et de services sociaux (CISSS) des Laurentides - Unité de recherche clini
Saint-Jérôme, Quebec, J7Z 5T3
Clinique des Maladies Lipidiques de Quebec Incorporated
Québec, Quebec, G1V 4W2
Clinique Sante Cardio MC
Montreal, Quebec, H1T 3Y7
Ecogene-21
Chicoutimi, Quebec, G7H 7K9
Institut de recherches cliniques de Montreal
Montreal, Quebec, H2W 1R7
Manna Research Incorporated
Lévis, Quebec, G6W 0M5
McGill University Health Centre - Montreal General Hospital
Montreal, Quebec, H3G 1A4

Results

See the results from the trial NCT03872401. This is an external link. The information is not authorized by the Government of Canada.

Date posted:
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