Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke
Last updated:
Last updated
The date of the most recent update for each trial record in the Canadian Clinical Trial Search Portal.
2026-07-11
Language and content disclaimer
The content and search results on this site are collected from or provided by third parties. As such some of the information may only be available in the language originally submitted by the sponsor of the trial. Learn more about the information on the search portal.
Linking to Non-Government of Canada Websites
Links to websites not under the control of the Government of Canada, including those to our social media accounts, and to clinical trial records in international registries are provided solely for the convenience of our website visitors. We are not responsible for the accuracy, currency or reliability of the content of such websites. The Government of Canada does not offer any guarantee in that regard and is not responsible for the information found through these links, nor does it endorse the sites and their content.
Visitors should also be aware that information offered by non-Government of Canada sites to which this website links is not subject to the Privacy Act or the Official Languages Act and may not be accessible to persons with disabilities. The information offered may be available only in the language(s) used by the sites in question. With respect to privacy, visitors should research the privacy policies of these non-government websites before providing personal information.
A DOUBLE-BLIND, RANDOMIZED, PLACEBO CONTROLLED, MULTICENTER STUDY TO EVALUATE THE IMPACT OF EVOLOCUMAB ON MAJOR CARDIOVASCULAR EVENTS IN PATIENTS AT HIGH CARDIOVASCULAR RISK WITHOUT PRIOR MYOCARDIAL INFARCTION OR STROKE
Intervention/treatment:
Intervention/treatment
Name given to the drug used in the clinical trial. This may be a code name, a chemical name of the active ingredient, a non-proprietary name or brand name.
REPATHA
Medical condition:
Medical condition
The disease or condition that's being studied in the clinical trial.
MAJOR CARDIOVASCULAR EVENTS
Protocol code:
Protocol Code
An alpha-numeric sequence generated by the sponsor that can vary in length. Used as a reference to help identify a specific clinical trial protocol. Formerly referred to as 'protocol number'.
20170625
Control number:
Control number
A unique 6-digit identification number Health Canada assigns to each clinical trial application.
225866
Status:
Trial Status
The status for the clinical trial as a whole. Note that the status for each site may be different and should always be confirmed with the clinical trial sponsor. Health Canada uses information provided by the sponsor to an international clinical trial registry to determine status values for each clinical trial. Status values on the portal can include:
• Not yet recruiting - Participants are not yet being recruited or enrolled at any site. • Recruiting - Participants are currently being recruited. • Active, not recruiting - The clinical trial is ongoing but new participants are not currently being recruited or enrolled. • On hold - The clinical trial has been temporarily stopped, but it may start again. • Closed - The clinical trial has either ended normally and participants are no longer being examined or treated, or it has stopped early and will not start again. • Unknown - The status of the clinical trial has not been verified in the registry in the last 2 years. Please contact the sponsor. • No match, ongoing - Please contact sponsor for status information. • Other - Please contact sponsor for status information.
Closed
Approved:
Approved
The date that the clinical trial has been determined to meet Health Canada’s regulatory requirements. For drug clinical trials, this means that a no objection letter or an authorization was issued.
April 17, 2019
Date Completed:
Date completed
The date of the last participant’s last visit in the global study. The completion date may be actual or estimated, depending what was provided to the registry. Estimated completion dates may be in the past or future.
Trial phase:
Trial phase
The stage of a clinical trial, based on factors such as the objectives of the trial and number of participants. Phase data displayed in the portal is taken from international registry data.
For more information see "Phases of drug trials" on the Definitions webpage
This is an external link. The information is not authorized by the Government of Canada.
Eligibility
Eligibility
The characteristics people must have or the requirements they must meet to participate in the clinical trial. Eligibility criteria include both inclusion criteria (must have for a person to participate) and exclusion criteria (prevent a person from participating).
Review the exact criteria from the registry or the sponsor before making a decision to participate. The following values may be available on the portal:
Sex: an eligibility criteria based on biological characteristics. Information in the portal is based on available data and will default to 'all' when no other data is available.
Age: The age a person must be to participate in the clinical trial.
Accepts Healthy Volunteers: People who do not have the disease or condition can participate in the clinical trial.
Sex:
ALL
Age
50 Years to 79 Years
Accepts healthy volunteers:
No
Contacts and locations
Contact
Contact
Information for an individual or organisation that can respond to questions about this clinical trial. This information comes from the international registry.
The sponsor conducts the clinical trial and is responsible for every aspect. For example this could be a company, a university or an individual researcher.
AMGEN CANADA INC
Locations
Alberta
LMC Clinical Research Incorporated
Calgary, Alberta, T2H 2G4
British Columbia
Dr T G Elliott Incorporated - BC Diabetes
Vancouver, British Columbia, V5Y 3W2
SMH Cardiology Clinical Trials Incorporated
Surrey, British Columbia, V3V 0C6
Manitoba
Winnipeg Clinic
Winnipeg, Manitoba, R3C 0N2
New Brunswick
G A Research Associates Limited
Moncton, New Brunswick, E1G 1A7
Newfoundland and Labrador
Commonwealth Medical Clinic
Mount Pearl, Newfoundland and Labrador, A1N 1W7
Nova Scotia
Queen Elizabeth II Health Sciences Centre, Halifax Infirmary
Halifax, Nova Scotia, B3H 3A7
Ontario
Bluewater Clinical Research Group Incorporated
Sarnia, Ontario, N7T 4X3
Brampton Clinical Trials
Brampton, Ontario, L6Z 4N5
Corcare Cardiovascular Research
Scarborough Village, Ontario, M1B 5N1
Dr James Cha
Oshawa, Ontario, L1J 2K1
Hamilton Health Sciences Hamilton General Hospital
Hamilton, Ontario, L8L 2X2
Heart Health Institute
Ajax, Ontario, L1Z 0B1
Heart Health Institute Research Incorporated
Scarborough Village, Ontario, M1B 4Z8
Kawartha Cardiology Clinical Trials
Peterborough, Ontario, K9J 0B2
LMC Clinical Research Incorporated
Barrie, Ontario, L4N 7L3
LMC Clinical Research Incorporated
Brampton, Ontario, L6S 0C6
LMC Clinical Research Incorporated
Etobicoke, Ontario, M9R 4E1
LMC Clinical Research Incorporated
Nepean, Ontario, K2J 0V2
LMC Clinical Research Incorporated Thornhill
Concord, Ontario, L4K 4M2
My Endo Diabetes and Endocrinology Center
Markham, Ontario, L3P 7P2
North York Diagnostic and Cardiac Centre
Toronto, Ontario, M6B 3H7
Oakville Cardiovascular Research
Oakville, Ontario, L6K 3W7
Office of Dr Louis Yao
Weston, Ontario, M9N 1W4
Partners in Advanced Cardiac Evaluation
Newmarket, Ontario, L3Y 2P6
SKDS Research Incorporated
Newmarket, Ontario, L3Y 5G8
Western Centre for Public Health and Family Medicine - Western University
London, Ontario, N6G 2M1
Womens College Hospital
Toronto, Ontario, M5S 1B2
Quebec
Applied Medical Informatics Research Incorporated
Montreal, Quebec, H4A 3T2
Centre intégré de santé et de services sociaux (CISSS) des Laurentides - Unité de recherche clini
Saint-Jérôme, Quebec, J7Z 5T3
Clinique des Maladies Lipidiques de Quebec Incorporated
Québec, Quebec, G1V 4W2
Clinique Sante Cardio MC
Montreal, Quebec, H1T 3Y7
Ecogene-21
Chicoutimi, Quebec, G7H 7K9
Institut de recherches cliniques de Montreal
Montreal, Quebec, H2W 1R7
Manna Research Incorporated
Lévis, Quebec, G6W 0M5
McGill University Health Centre - Montreal General Hospital