Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

Last updated:
2026-07-11
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View trial details

Overview

Official protocol title:

A PHASE III TRIAL OF STEREOTACTIC RADIOSURGERY COMPARED WITH HIPPOCAMPAL-AVOIDANT WHOLE BRAIN RADIOTHERAPY (HA-WBRT) PLUS MEMANTINE FOR 5 OR MORE BRAIN METASTASES

Intervention/treatment:
MEMANTINE
Medical condition:
BRAIN METASTASES
Protocol code:
CE.7
Control number:
215052
Status:
Recruiting
Approved:
April 27, 2018
Trial phase:
Phase 3
For more information:
ClinicalTrials.gov - NCT03550391
This is an external link. The information is not authorized by the Government of Canada.

Eligibility

Sex: ALL
Age
18 Years and older
Accepts healthy volunteers: No

Contacts and locations

Contact
Name
Chris O'Callaghan
Role
CONTACT
Phone:
613-533-6430
Sponsor
CANADIAN CANCER TRIALS GROUP, CANCER RESEARCH INSTITUTE, QUEEN'S UNIVERSITY

Locations

Alberta

Arthur J E Child Comprehensive Cancer Centre
Calgary, Alberta, T2N 5G2
RECRUITING
Name
Site Public Contact
Role
CONTACT
Phone:
888-823-5923
Name
Muhammad S. Faruqi
Role
PRINCIPAL_INVESTIGATOR
Cross Cancer Institute
Edmonton, Alberta, T6G 1Z2
RECRUITING
Name
Site Public Contact
Role
CONTACT
Phone:
780-432-8500
Name
Samir I. Patel
Role
PRINCIPAL_INVESTIGATOR

British Columbia

BCCA-Vancouver Cancer Centre
Vancouver, British Columbia, V5Z 4E6
RECRUITING
Name
Site Public Contact
Role
CONTACT
Phone:
888-939-3333
Name
Alan M. Nichol
Role
PRINCIPAL_INVESTIGATOR

Nova Scotia

QEII Health Sciences Centre/Nova Scotia Health Authority
Halifax, Nova Scotia, B3H 2Y9
RECRUITING
Name
Site Public Contact
Role
CONTACT
Phone:
902-473-6000
Name
Michael N. Ha
Role
PRINCIPAL_INVESTIGATOR

Ontario

Juravinski Cancer Centre at Hamilton Health Sciences
Hamilton, Ontario, L8V 5C2
ACTIVE_NOT_RECRUITING
Name
Site Public Contact
Role
CONTACT
Phone:
905-387-9495
Name
Jeffrey N. Greenspoon
Role
PRINCIPAL_INVESTIGATOR
London Regional Cancer Program
London, Ontario, N6A 4L6
RECRUITING
Name
Site Public Contact
Role
CONTACT
Phone:
519-685-8600
Name
Melody Qu
Role
PRINCIPAL_INVESTIGATOR
University Health Network-Princess Margaret Hospital
Toronto, Ontario, M5G 2M9
RECRUITING
Name
Site Public Contact
Role
CONTACT
Phone:
416-946-4501
Name
David B. Shultz
Role
PRINCIPAL_INVESTIGATOR

Quebec

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Sherbrooke, Quebec, J1H 5N4
SUSPENDED
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)
Québec, Quebec, G1R 2J6
RECRUITING
Name
Site Public Contact
Role
CONTACT
Name
Isabelle Thibault
Role
PRINCIPAL_INVESTIGATOR
CHUM - Centre Hospitalier de l'Universite de Montreal
Montreal, Quebec, H2X 3E4
RECRUITING
Name
Site Public Contact
Role
CONTACT
Phone:
514-890-8000
Extension 12725
Name
David Roberge
Role
PRINCIPAL_INVESTIGATOR
CSSS Champlain-Charles Le Moyne
Greenfield Park, Quebec, J4V 2H1
SUSPENDED
Jewish General Hospital
Montreal, Quebec, H3T 1E2
RECRUITING
Name
Site Public Contact
Role
CONTACT
Phone:
514-340-8222
Extension 8248
Name
Thierry M. Muanza
Role
PRINCIPAL_INVESTIGATOR
The Research Institute of the McGill University Health Centre (MUHC)
Montreal, Quebec, H3H 2R9
SUSPENDED
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