EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR-Preserved)
Last updated:
Last updated
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2026-07-11
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A PHASE III RANDOMISED, DOUBLE-BLIND TRIAL TO EVALUATE EFFICACY AND SAFETY OF ONCE DAILY EMPAGLIFLOZIN 10 MG COMPARED TO PLACEBO, IN PATIENTS WITH CHRONIC HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF)
Intervention/treatment:
Intervention/treatment
Name given to the drug used in the clinical trial. This may be a code name, a chemical name of the active ingredient, a non-proprietary name or brand name.
EMPAGLIFLOZIN
Medical condition:
Medical condition
The disease or condition that's being studied in the clinical trial.
HEART FAILURE
Protocol code:
Protocol Code
An alpha-numeric sequence generated by the sponsor that can vary in length. Used as a reference to help identify a specific clinical trial protocol. Formerly referred to as 'protocol number'.
1245.110
Control number:
Control number
A unique 6-digit identification number Health Canada assigns to each clinical trial application.
201575
Status:
Trial Status
The status for the clinical trial as a whole. Note that the status for each site may be different and should always be confirmed with the clinical trial sponsor. Health Canada uses information provided by the sponsor to an international clinical trial registry to determine status values for each clinical trial. Status values on the portal can include:
• Not yet recruiting - Participants are not yet being recruited or enrolled at any site. • Recruiting - Participants are currently being recruited. • Active, not recruiting - The clinical trial is ongoing but new participants are not currently being recruited or enrolled. • On hold - The clinical trial has been temporarily stopped, but it may start again. • Closed - The clinical trial has either ended normally and participants are no longer being examined or treated, or it has stopped early and will not start again. • Unknown - The status of the clinical trial has not been verified in the registry in the last 2 years. Please contact the sponsor. • No match, ongoing - Please contact sponsor for status information. • Other - Please contact sponsor for status information.
Closed
Approved:
Approved
The date that the clinical trial has been determined to meet Health Canada’s regulatory requirements. For drug clinical trials, this means that a no objection letter or an authorization was issued.
January 18, 2017
Date Completed:
Date completed
The date of the last participant’s last visit in the global study. The completion date may be actual or estimated, depending what was provided to the registry. Estimated completion dates may be in the past or future.
Trial phase:
Trial phase
The stage of a clinical trial, based on factors such as the objectives of the trial and number of participants. Phase data displayed in the portal is taken from international registry data.
For more information see "Phases of drug trials" on the Definitions webpage
This is an external link. The information is not authorized by the Government of Canada.
Eligibility
Eligibility
The characteristics people must have or the requirements they must meet to participate in the clinical trial. Eligibility criteria include both inclusion criteria (must have for a person to participate) and exclusion criteria (prevent a person from participating).
Review the exact criteria from the registry or the sponsor before making a decision to participate. The following values may be available on the portal:
Sex: an eligibility criteria based on biological characteristics. Information in the portal is based on available data and will default to 'all' when no other data is available.
Age: The age a person must be to participate in the clinical trial.
Accepts Healthy Volunteers: People who do not have the disease or condition can participate in the clinical trial.
Sex:
ALL
Age
18 Years and older
Accepts healthy volunteers:
No
Contacts and locations
Contact
Contact
Information for an individual or organisation that can respond to questions about this clinical trial. This information comes from the international registry.
The sponsor conducts the clinical trial and is responsible for every aspect. For example this could be a company, a university or an individual researcher.
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Locations
Alberta
Royal Alexandra Hospital
Edmonton, Alberta, T5H 3V9
British Columbia
Medical Arts Health Research Group
North Vancouver, British Columbia, V7M 2H4
Vancouver General Hospital
Vancouver, British Columbia, V5Z 1M9
Victoria Heart Institute Foundation
Victoria, British Columbia, V8R 1B2
Manitoba
St. Boniface General Hospital
Winnipeg, Manitoba, R2H 2A6
New Brunswick
G.A. Research Associates Ltd
Moncton, New Brunswick, E1G 1A7
Nova Scotia
QEII Health Sciences Centre
Halifax, Nova Scotia, B3H 3A7
Ontario
Brampton Cardio Pulmonary Clinic
Brampton, Ontario, L6W 2X7
Brampton Research Associates
Brampton, Ontario, L6Z 4N5
Cambridge Cardiac Care Inc.
Cambridge, Ontario, N1R 6V6
Canadian Phase Onward Inc.
Toronto, Ontario, M3J 0K2
Cardiovascular Contract Research Organization LTD
Greater Sudbury, Ontario, P3E 3Y9
Curnew Medicine Professional Corporation
Hamilton, Ontario, L8L 0A9
Dr. Louis C.H. Yao
York, Ontario, M9N 1W4
Dr. Saul Vizel
Cambridge, Ontario, N1R 7R1
Hamilton General Hospital
Hamilton, Ontario, L8L 2X2
Heart Health Institute
Scarborough Village, Ontario, M1B 4Z8
JBN Medical Diagnostic Services Inc.
Burlington, Ontario, L7M 4Y1
Kawartha Cardiology Clinical Trials
Peterborough, Ontario, K9J 0B2
M Heffernan Medicine Professional Corp.
Oakville, Ontario, L6K 3W7
Mohan Babapulle Medicine Professional Medicine
Waterloo, Ontario, N2T 0C1
North York Diagnostic and Cardiac Centre
Toronto, Ontario, M6B 1N6
PACE (Partners in Advanced Cardiac Evaluation)
Newmarket, Ontario, L3Y 2P6
Scarborough Cardiology Research
Scarborough Village, Ontario, M1E 5E9
University Hospital (LHSC)
London, Ontario, N6A 5A5
Quebec
Centre de Dépistage et Recherche Cardiovasculaire Rive-Sud
Longeuil, Quebec, J4M 2X1
Clinique Santé Cardio MC
Montreal, Quebec, H1T 3Y7
IUCPQ (Laval University)
Québec, Quebec, G1V 4G5
McGill University Health Centre (MUHC)
Montreal, Quebec, H4A 3J1
Montreal General Hospital - McGill University Health Centre