A Study of Ocrelizumab in Participants With Relapsing Remitting Multiple Sclerosis (RRMS) Who Have Had a Suboptimal Response to an Adequate Course of Disease-Modifying Treatment (DMT)
Last updated:
Last updated
The date of the most recent update for each trial record in the Canadian Clinical Trial Search Portal.
2026-07-11
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AN OPEN-LABEL STUDY TO EVALUATE THE EFFECTIVENESS AND SAFETY OF OCRELIZUMAB IN PATIENTS WITH RELAPSING REMITTING MULTIPLE SCLEROSIS WHO HAVE HAD A SUBOPTIMAL RESPONSE TO AN ADEQUATE COURSE OF DISEASE-MODIFYING TREATMENT
Intervention/treatment:
Intervention/treatment
Name given to the drug used in the clinical trial. This may be a code name, a chemical name of the active ingredient, a non-proprietary name or brand name.
OCRELIZUMAB (RO-496-4913, PRO70769, RHUMAB 2H7)
Medical condition:
Medical condition
The disease or condition that's being studied in the clinical trial.
MULTIPLE SCLEROSIS
Protocol code:
Protocol Code
An alpha-numeric sequence generated by the sponsor that can vary in length. Used as a reference to help identify a specific clinical trial protocol. Formerly referred to as 'protocol number'.
MN30035
Control number:
Control number
A unique 6-digit identification number Health Canada assigns to each clinical trial application.
191195
Status:
Trial Status
The status for the clinical trial as a whole. Note that the status for each site may be different and should always be confirmed with the clinical trial sponsor. Health Canada uses information provided by the sponsor to an international clinical trial registry to determine status values for each clinical trial. Status values on the portal can include:
• Not yet recruiting - Participants are not yet being recruited or enrolled at any site. • Recruiting - Participants are currently being recruited. • Active, not recruiting - The clinical trial is ongoing but new participants are not currently being recruited or enrolled. • On hold - The clinical trial has been temporarily stopped, but it may start again. • Closed - The clinical trial has either ended normally and participants are no longer being examined or treated, or it has stopped early and will not start again. • Unknown - The status of the clinical trial has not been verified in the registry in the last 2 years. Please contact the sponsor. • No match, ongoing - Please contact sponsor for status information. • Other - Please contact sponsor for status information.
Closed
Approved:
Approved
The date that the clinical trial has been determined to meet Health Canada’s regulatory requirements. For drug clinical trials, this means that a no objection letter or an authorization was issued.
February 10, 2016
Date Completed:
Date completed
The date of the last participant’s last visit in the global study. The completion date may be actual or estimated, depending what was provided to the registry. Estimated completion dates may be in the past or future.
Trial phase:
Trial phase
The stage of a clinical trial, based on factors such as the objectives of the trial and number of participants. Phase data displayed in the portal is taken from international registry data.
For more information see "Phases of drug trials" on the Definitions webpage
This is an external link. The information is not authorized by the Government of Canada.
Eligibility
Eligibility
The characteristics people must have or the requirements they must meet to participate in the clinical trial. Eligibility criteria include both inclusion criteria (must have for a person to participate) and exclusion criteria (prevent a person from participating).
Review the exact criteria from the registry or the sponsor before making a decision to participate. The following values may be available on the portal:
Sex: an eligibility criteria based on biological characteristics. Information in the portal is based on available data and will default to 'all' when no other data is available.
Age: The age a person must be to participate in the clinical trial.
Accepts Healthy Volunteers: People who do not have the disease or condition can participate in the clinical trial.
Sex:
ALL
Age
18 Years to 55 Years
Accepts healthy volunteers:
No
Contacts and locations
Contact
Contact
Information for an individual or organisation that can respond to questions about this clinical trial. This information comes from the international registry.
The sponsor conducts the clinical trial and is responsible for every aspect. For example this could be a company, a university or an individual researcher.
GENENTECH INC
Locations
Alberta
Foothills Medical Centre; Centre Dept of Medical Clinical Neuroscience
Calgary, Alberta, T2N 2T9
University of Alberta; Divison of Pulmonary Medicine, Dept. of Medicine,
Edmonton, Alberta, T6C 2G3
British Columbia
CHU De Quebec Universite Laval
Québec, British Columbia, G1J 1Z4
Fraser Health Multiple Sclerosis Clinic; Burnaby Hospital Pharmacy
Burnaby, British Columbia, V5G 2X6
New Brunswick
Horizon Health Network - Multiple Sclerosis Clinic
Saint John, New Brunswick, E2L 4L2
Nova Scotia
Dalhousie Multiple Sclerosis Research Unit
Halifax, Nova Scotia, B3H 4K4
Ontario
Hamilton General Hospital
Hamilton, Ontario, L8L 2X2
St. Michael's Hospital MS Clinic, MS Research Centre
Toronto, Ontario, H3A 2B4
The Ottawa Hospital - General Campus; Department of Neurology - Multiple Sclerosis
Ottawa, Ontario, K1H 8L6
Quebec
Chum Campus Notre Dame
Montreal, Quebec, H2X 0A9
Clinique NeuroOutaouais
Gatineau, Quebec, J8Y 1W2
Hopital Hotel Dieu de Levis
Lévis, Quebec, G6V 3Z1
McGill University; Montreal Neurological Institute; Neurological and Psychiatric
